So this might be going a little off-topic but I figured I would bring it up, since I made this graphic already and all.
(Originally I misread the topic as brainstorming to re-arrange menus mnemonically. In hindsight, changing default hotkeys is a great way to piss off your active playerbase.)
But, if anyone wanted to be really hardcore with their hotkey layout, rearrange hotkeys based on finger movement. The most common build items should be placed on the closest keys. For example, the economy menu opens with 'E', so the most common items should be placed closer to 'E'.
Mex is the most common/important of all economy structures, so it stays at 1. The two 2 positions might be for wind and solar. Caretaker probably on 3, fusion on 4, and then it doesn't really matter that much between geo and superfusion on 5 and 6.
An idea just in case anyone wanted to be a serious hard-ass pro with their keybinds.